منابع مشابه
Cardioprotection and ageing
With an increase in the elderly population and an increase in the prevalence of age-related cardiovascular disease, anesthesiologists are increasingly being faced with elderly patients with known or suspected ischemic heart disease in the perioperative period. Although early reperfusion remains the best strategy to reduce ischemic injury, reperfusion may damage the myocardium. Adjuvant therapy ...
متن کاملLoss of cardioprotection with ageing.
Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is higher in older than in young humans, and the demographic shift towards an ageing population will further increase the prevalence of age-related cardiovascular disease. In order to develop strategies aimed to limit reversible and irreversible myocardial damage in older patients, there is a need to better ...
متن کاملSex differences in nutrient-dependent reproductive ageing.
Evolutionary theories of aging predict that fitness-related traits, including reproductive performance, will senesce because the strength of selection declines with age. Sexual selection theory predicts, however, that male reproductive performance (especially sexual advertisement) will increase with age. In both bodies of theory, diet should mediate age-dependent changes in reproductive perform...
متن کاملMechanisms of sex differences in TNFR2-mediated cardioprotection.
BACKGROUND TNFR1/TNFR2 signaling may mediate different cellular and molecular responses (injury versus protection) and the balance may be affected by sex hormones. Previous studies have shown that females have improved myocardial functional recovery, TNFR1 signaling resistance, and increased SOCS3 expression after acute ischemia/reperfusion when compared with males. However, it is unknown wheth...
متن کاملSex and Ageing: The Role of Sexual Recombination in Longevity
I use a set of machines based on the concept of nested rule systems built on the a modified version of the Wolfram elemental cellular automata to investigate the role of recombination in providing resistance to ageing. Class III and class IV machines are observed to respond differently to recombination. Class IV machines show recombinational centring in their neutral networks whereas class III ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2020
ISSN: 0007-1188,1476-5381
DOI: 10.1111/bph.14951